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KMID : 1101320050370020061
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Korean Journal of Clinical Laboratory Science
2005 Volume.37 No. 2 p.61 ~ p.64
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Comparison of Protein Electrophoresis Fractions in Diabetes Patient Serum
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Kim Chong-Ho
Park Seok-Tae
Park Hyea-Rim
Park Seung-Taeck
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Abstract
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We compared the serum protein electrophoresis patterns in sera of diabetes patients (n=166) which showed more than 150 mg/dL of glucose. The concentrations of total protein, albumin, α1-globulin, α2-globulin, β -globulin and γ-globulin in sera of patients were 6.3±1.2 g/dL, 40.3±6.4%, 4.9±2.3%, 13.5±3.8%, 15.5±3.9%, and 25.9±5.8%, respectively. The frequency of patients showed lower levels of total protein, albumin, α1- globulin were 48.5%, 96.4%, and 33.7%. The frequency of patients showed higher levels of α2-globulin, β- globulin, and γ-globulin were 56.6%, 47.0%, and 90.4%, respectively. This data suggests that the high concentration of glucose in blood may damage the kidney and liver. Also, the decrease of albumin and α 1-globulin and increase of α2-globulin, β-globulin and γ-globulin shows that the concentration of glucose in blood will have an effect on the variation of serum protein electrophoretic patterns.
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KEYWORD
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Glucose, Total protein, EP, Hyperglycemia, Serum
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